N,N,Carbonyldiimidazole (CDI)

Name: N,N,Carbonyldiimidazole (CDI)
Brand: SHILPA CHEMSPEC INTERNATIONAL PRIVATE LIMITED
Price: 1 INR
Availability: InStock

1 INR/Kilograms

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Product Details:

Ph Level Not applicable (neutral)
Properties White to off-white solid, moisture sensitive, stable under dry conditions, decomposes in presence of water or moisture
Molecular Formula C7H6N4O
Shape Crystalline
Grade Industrial, Laboratory, Pharmaceutical
Structural Formula ![Structural Formula](https://pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?cid=10357&t=l)
Physical Form Powder
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N,N,Carbonyldiimidazole (CDI) Price And Quantity

Price 1 INR/Kilograms
Minimum Order Quantity 1 Kilograms

N,N,Carbonyldiimidazole (CDI) Product Specifications

Product Type Active Chemical Ingredients
HS Code 2933.59.90
EINECS No 208-488-9
Usage Used in organic synthesis, pharmaceuticals, peptide and ester formation
Poisonous Yes (handle with care, toxic on inhalation, ingestion, and skin contact)
Taste Bitter
Density 1.44 Gram per cubic centimeter(g/cm3)
Solubility Soluble in acetone, DMF, DMSO; slightly soluble in water
Grade Industrial, Laboratory, Pharmaceutical
Physical Form Powder
Structural Formula ![Structural Formula](https://pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?cid=10357&t=l)
Properties White to off-white solid, moisture sensitive, stable under dry conditions, decomposes in presence of water or moisture
Ph Level Not applicable (neutral)
Shape Crystalline
Molecular Formula C7H6N4O
Melting Point 117122C
CAS No 530-62-1
Molecular Weight 162.15 g/mol
Smell Odorless or slight amine-like odor
Shelf Life 2 years in unopened container under recommended storage conditions
Ingredients N,N-Carbonyldiimidazole
Application Reagent for peptide and ester synthesis; coupling and condensing agent; pharmaceutical intermediate
Appearance White to off-white crystalline powder
Storage Store in tightly sealed container, dry, cool, well-ventilated area; protect from moisture and light
Purity 99%

N,N,Carbonyldiimidazole (CDI) Trade Information

Supply Ability 25 Kilograms Per Week
Delivery Time 3-4 Week

Product Description

N,N,Carbonyldiimidazole (CDI)

Analysis Item	Specification
Purity %	98.0% Min
Appearance	White To Off white Crystalline Powder
Melting Point	116.0 122.0oC

Applications of N,N,Carbonyldiimidazole (CDI)

N,N-Carbonyldiimidazole (CD1) is a zero length crosslinking reagent used to couple primary amines to carboxyllic acid functional groups. CDI reacts with the carboxylate ion (COO-) of proteins or other organic compounds, forming a reactive intermediate that is subsequently reacted with an amino group (-NH2).
This reagent can be used to couple two proteins, and is commonly used in protein immobilization to a solid support or membrane. Conveniently, CDI can be used in both aqueous and organic solvent systems.
N,N, Carbonyl diimidazole (CDI) is a useful alternative to highly toxic phosgene. CDI is similar to phosgene in its synthetic utility but is easier to handle since it exists as a solid. CDI is moisture sensitive and reacts readily with H2O to evolve CO2. CDI can be used for the activation of carboxylic acids. These activated carboxylic acids can be reacted with nucleophiles to make product that such as amides, esters, ureas, and carbamates. CDI reactions often dont require a base because the liberated imidazole anion acts a base.

High Efficiency in Synthesis

CDI displays exceptional performance as a coupling and condensing agent for peptide and ester formation. Its ability to react efficiently under anhydrous conditions makes it highly valuable in both laboratory and industrial settings. CDI facilitates a streamlined process with high purity yields, essential for pharmaceutical intermediates and organic chemistry applications.

Safe Handling and Packaging

Due to its corrosive, toxic, and irritant nature, CDI is packaged in robust, tightly sealed HDPE bottles that protect it from moisture and environmental exposure. Adhering to recommended handling instructions ensures user safety and maintains product stability. Custom packaging options accommodate varying scale and storage needs for diverse users.

Storage and Shelf Life Guidelines

Maintaining a dry, cool, and well-ventilated storage environment is vital for preserving CDIs quality. The compound remains stable for up to two years when stored in an unopened container, protected from moisture and light. These optimal storage conditions prevent degradation and maintain efficacy for demanding synthesis tasks.

FAQs of N,N,Carbonyldiimidazole (CDI):

Q: How should N,N-Carbonyldiimidazole (CDI) be stored to maintain its stability?

A: CDI should be stored in a tightly sealed container, in a dry, cool, and well-ventilated area. Exposure to moisture or humidity can cause the compound to degrade, so storing it away from water and light is essential for maintaining its stability and prolonging its shelf life.

Q: What are the primary applications and benefits of using CDI in organic synthesis?

A: CDI is mainly used as a coupling and condensing agent in the synthesis of peptides and esters and as an intermediate in pharmaceutical manufacturing. Its primary benefit is enabling efficient and high-yielding reactions under anhydrous conditions, with high purity suitable for critical applications.

Q: What personal protective equipment (PPE) is required when handling CDI?

A: Due to its corrosive and toxic properties, it is necessary to use gloves, safety goggles, lab coats, and, where needed, a respirator. All handling should take place in a well-ventilated environment or chemical fume hood to minimize the risk of skin, eye, and respiratory irritation.

Q: When is CDI typically used during the synthesis process?

A: CDI is added during the coupling or activation step of peptide and ester synthesis. It acts as an efficient activating agent for carboxylic acids, which allows for subsequent reaction with nucleophiles to form amide or ester bonds, significantly streamlining complex organic syntheses.

Q: Where can CDI be sourced, and in what packaging sizes is it available?

A: CDI is distributed and supplied across India by reputable manufacturers and traders. It is available in standard 25 g, 100 g, 500 g, and 1 kg HDPE bottles, with the option for customized packaging to suit specific research or industrial requirements.

Q: What precautions must be taken during the transport and storage of CDI?

A: Though not regulated as a dangerous good for transport, CDI must be protected from moisture and physical damage during shipping and storage. Containers should remain tightly closed, and the compound must not be exposed to water or humid environments to prevent decomposition.

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