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TRIMETHYL ORTHOFORMATE

TRIMETHYL ORTHOFORMATE
TRIMETHYL ORTHOFORMATE
Product Code : 19
Product Description
Trimethyl Orthoformate

Analysis Item

Specification

Purity: (GC)

99.2% Min

Appearance

Colorless Transparent Liquid

Methyl Formate

0.20% Max

Methanol

030% Max

Colority (APHA)

10 Max

Water

005 %Max


Trimethyl orthoformate is the simplest orthoester. It is a reagent used in organic synthesis for the introduction of a protecting groupfor aldehydes. The product of reaction of an aldehyde with trimethyl orthoformate is an acetal. In general cases, these acetals can be deprotected back to the aldehyde by using hydrochloric acid.

The industrial synthesis of this chemical is from hydrogen cyanide and methanol.

Trimethyl orthoformate is a useful building block for creating methoxymethylene groups and heterocyclic ring systems. It introduces a formyl group to a nucleophilic substrate, e.g. RNHz to form R-NH-CHO, which can undergo further reactions. It is used in the production of the fungicides, azoxystrobin and picoxystrobin, as well as for some members of the floxacin family of antibacterial drugs. A number of pharmaceutical intermediates are also made from trimethyl orthoformate.
Trimethyl Orthoromate also find application in Aromatic Fragrance Manufacturing Industry.



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